Space-time wiring specificity supports direction selectivity in the retina

被引：310

作者：

Kim, Jinseop S. ^{[1
]}

Greene, Matthew J. ^{[1
]}

Zlateski, Aleksandar ^{[2
]}

Lee, Kisuk ^{[1
]}

Richardson, Mark ^{[1
]}

Turaga, Srinivas C. ^{[1
]}

Purcaro, Michael ^{[1
]}

Balkam, Matthew ^{[1
]}

Robinson, Amy ^{[1
]}

Behabadi, Bardia F. ^{[3
]}

Campos, Michael ^{[3
]}

Denk, Winfried ^{[4
]}

Seung, H. Sebastian ^{[1
]}

机构：

[1] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[3] Qualcomm Res, San Diego, CA 92121 USA

[4] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

来源：

NATURE | 2014年 / 509卷 / 7500期

基金：

美国国家卫生研究院;

关键词：

BIPOLAR CELLS; DENDRITES; MECHANISM; CIRCUIT; MODELS; MAP;

D O I：

10.1038/nature13240

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

How does the mammalian retina detect motion? This classic problem in visual neuroscience has remained unsolved for 50 years. In search of clues, here we reconstruct Off-type starburst amacrine cells (SACs) and bipolar cells (BCs) in serial electron microscopic images with help from EyeWire, an online community of 'citizen neuroscientists'. On the basis of quantitative analyses of contact area and branch depth in the retina, we find evidence that one BC type prefers to wire with a SAC dendrite near the SAC soma, whereas another BC type prefers to wire far from the soma. The near type is known to lag the far type in time of visual response. A mathematical model shows how such 'space-time wiring specificity' could endow SAC dendrites with receptive fields that are oriented in space-time and therefore respond selectively to stimuli that move in the outward direction from the soma.

引用

页码：331 / +

页数：17

共 46 条

[1] SPATIOTEMPORAL ENERGY MODELS FOR THE PERCEPTION OF MOTION [J].

ADELSON, EH ;

BERGEN, JR .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1985, 2 (02) :284-299

[2]

[Anonymous], 2009, Advances in Neural Information Processing Systems

[3] Fast and slow contrast adaptation in retinal circuitry [J].

Baccus, SA ;

Meister, M .

NEURON, 2002, 36 (05) :909-919

[4] Spikes in Mammalian Bipolar Cells Support Temporal Layering of the Inner Retina [J].

Baden, Tom ;

Berens, Philipp ;

Bethge, Matthias ;

Euler, Thomas .

CURRENT BIOLOGY, 2013, 23 (01) :48-52

[5] MECHANISM OF DIRECTIONALLY SELECTIVE UNITS IN RABBITS RETINA [J].

BARLOW, HB ;

LEVICK, WR .

JOURNAL OF PHYSIOLOGY-LONDON, 1965, 178 (03) :477-&

[6]

Berry MJ, 1998, J NEUROSCI, V18, P2200

[7] A quantitative map of the circuit of cat primary visual cortex [J].

Binzegger, T ;

Douglas, RJ ;

Martin, KAC .

JOURNAL OF NEUROSCIENCE, 2004, 24 (39) :8441-8453

[8]

Borg-Graham L.J., 1992, Single Neuron Computation, pages, P347

[9] Two-Photon Imaging of Nonlinear Glutamate Release Dynamics at Bipolar Cell Synapses in the Mouse Retina [J].

Borghuis, Bart G. ;

Marvin, Jonathan S. ;

Looger, Loren L. ;

Demb, Jonathan B. .

JOURNAL OF NEUROSCIENCE, 2013, 33 (27) :10972-10985

[10] Adaptation of response transients in fly motion vision. II: Model studies [J].

Borst, A ;

Reisenman, C ;

Haag, J .

VISION RESEARCH, 2003, 43 (11) :1309-1322

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