A novel targeting drug carrier to deliver chemical bonded and physical entrapped anti-tumor drugs

被引：8

作者：

Huang, Ling ^{[1
,2
]}

Song, Jinchun ^{[3
]}

Chen, Bangyin ^{[2
]}

机构：

[1] Wuhan Docan Pharmaceut Co Ltd, Wuhan 430040, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China

[3] Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 466卷 / 1-2期

关键词：

Targeting; Drug carrier; Entrapped; Anti-tumor drugs; COMBINED DOXORUBICIN; PH; COPOLYMER; MICELLES; CANCER; FOLATE; NANOPARTICLES; CHEMOTHERAPY; PACLITAXEL; PRODRUGS;

D O I：

10.1016/j.ijpharm.2014.03.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, we demonstrated a novel targeting drug carrier formed by amphiphilic prodrug based mixed micelle. Along with octadecyl chains, chemical bonded Dox moieties were utilized to entrap free drugs (PTX) and simultaneously acted as therapeutic agents. The formulation of CP-Folate/CPN = Dox/PTX showed spherical micellar structure and possessed high drug loading content, which was up to 22.9%. We examined the cell uptaken capacity and the cytotoxicity of mixed micelle by CLSM and MTT assay. The introducing of folate moiety enhanced intracellular accumulation in HeLa cells and co-delivery of Dox and PTX showed stronger anti-tumor activity even compared with free drugs. (C) 2014 Elsevier B. V. All rights reserved.

引用

页码：52 / 57

页数：6

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