Synthesis of Arylethyl (E)-Styrylsulfones and Arylsulfones by One-Pot DIBAL-H/NaH-Mediated Reaction of β-Ketosulfones

被引：18

作者：

Chang, Meng-Yang ^{[1
]}

Chen, Yi-Chia ^{[1
]}

Chan, Chieh-Kai ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

来源：

SYNLETT | 2014年 / 25卷 / 12期

关键词：

aldol reaction; aluminum; condensation; sulfones; tandem reaction; UNSYMMETRICAL DIARYL SULFONES; KETO-SULFONES; ACID SALTS; ARYL; FACILE; SULFONYLATION; SULFOXIDES; VERSATILE; CATALYST; HALIDES;

D O I：

10.1055/s-0033-1339117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot synthetic route for preparing a series of arylethyl (E)-styrylsulfones or arylethyl arylsulfones is developed. The efficient one-pot DIBAL-H/NaH-mediated route includes reduction of -benzyl--arylketosulfones and retroaldol/aldol or retroaldol reaction of the resulting intermediate. The DIBAL-H/NaH-mediated reaction mechanism has been discussed.

引用

页码：1739 / 1744

页数：6

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