Gold(i)-catalyzed enantioselective synthesis of polycyclic indoline skeletons and enantiomerically enriched β-substituted tryptamine-allenes by kinetic resolution

被引：14

作者：

Zhang, Yan-Yan ^{[1
]}

Wei, Yin ^{[1
]}

Shi, Min ^{[1
,2
,3
]}

机构：

[1] Univ Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, 345 Ling Ling Lu, Shanghai 200032, Peoples R China

[2] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[3] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 29期

基金：

中国国家自然科学基金;

关键词：

CYCLOADDITIONS; LIGANDS; HETEROCYCLES; BORREVERINE; CATALYSIS; HYDROARYLATION; CYCLIZATION;

D O I：

10.1039/c9cc00412b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A gold(i)-catalyzed highly efficient kinetic resolution of indole-allene derivatives has been demonstrated, providing enantiomerically enriched polycyclic indolines possessing four stereogenic centers including an all-carbon quaternary center in a spirocyclic framework and -substituted tryptamine derivatives in good to excellent ee values and high s selectivities with good functional group tolerance under mild conditions in an atom-economical way.

引用

页码：4210 / 4213

页数：4

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