Correlation of human S100A12 (EN-RAGE) and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes

被引：23

作者：

Pradeep, A. R. ^{[1
]}

Martande, Santosh S. ^{[1
]}

Singh, Sonender Pal ^{[1
]}

Suke, Deepak Kumar ^{[1
]}

Raju, Arjun P. ^{[2
]}

Naik, Savitha B. ^{[3
]}

机构：

[1] Govt Dent Coll & Res Inst, Dept Periodont, Bangalore 560002, Karnataka, India

[2] Bangalore Med Coll & Res Inst, Bangalore 560002, Karnataka, India

[3] Govt Dent Coll & Res Inst, Dept Conservat Dent & Endodont, Bangalore 560002, Karnataka, India

来源：

INFLAMMATION RESEARCH | 2014年 / 63卷 / 04期

关键词：

Chronic periodontitis; Inflammation; Diabetes mellitus; Gingival crevicular fluid; Biomarkers; NECROSIS-FACTOR-ALPHA; NEUTROPHIL; RECEPTOR; DISEASE; INTERLEUKIN-6; ASSOCIATION; ACTIVATION; EXPRESSION; PATHWAY; RISK;

D O I：

10.1007/s00011-013-0703-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM). A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of human S100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated. Both human S100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05). Human S100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM.

引用

页码：317 / 323

页数：7

共 35 条

[1] Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies [J].

Barba, C ;

Cavalli-Sforza, T ;

Cutter, J ;

Darnton-Hill, I ;

Deurenberg, P ;

Deurenberg-Yap, M ;

Gill, T ;

James, P ;

Ko, G ;

Miu, AH ;

Kosulwat, V ;

Kumanyika, S ;

Kurpad, A ;

Mascie-Taylor, N ;

Moon, HK ;

Nishida, C ;

Noor, MI ;

Reddy, KS ;

Rush, E ;

Schultz, JT ;

Seidell, J ;

Stevens, J ;

Swinburn, B ;

Tan, K ;

Weisell, R ;

Wu, ZS ;

Yajnik, CS ;

Yoshiike, N ;

Zimmet, P .

LANCET, 2004, 363 (9403) :157-163

[2] Response to comment on: American Diabetes Association. Standards of medical care in diabetes-2011 (vol 34, pg e54, 2011) [J].

Wysham, C. H. ;

Kirkman, M. S. .

DIABETES CARE, 2011, 34 (08) :1887-1887

[3] Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism [J].

Blüher, M ;

Fasshauer, M ;

Tönjes, A ;

Kratzsch, J ;

Schön, MR ;

Paschke, R .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2005, 113 (09) :534-537

[4] Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type [J].

Donato, R .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1999, 1450 (03) :191-231

[5] Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis [J].

Foell, D ;

Kane, D ;

Bresnihan, B ;

Vogl, T ;

Nacken, W ;

Sorg, C ;

FitzGerald, O ;

Roth, J .

RHEUMATOLOGY, 2003, 42 (11) :1383-1389

[6] Expression of S100A12 (EN-RAGE) in cystic fibrosis [J].

Foell, D ;

Seeliger, S ;

Vogl, T ;

Koch, HG ;

Maschek, H ;

Harms, E ;

Sorg, C ;

Roth, J .

THORAX, 2003, 58 (07) :613-617

[7] Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease [J].

Foell, D ;

Kucharzik, T ;

Kraft, M ;

Vogl, T ;

Sorg, C ;

Domschke, W ;

Roth, J .

GUT, 2003, 52 (06) :847-853

[8]

GLAVIND LEIF, 1967, J PERIODONTAL RES, V2, P180, DOI 10.1111/j.1600-0765.1967.tb01887.x

[9] IDENTIFICATION AND CHARACTERIZATION OF A NOVEL HUMAN NEUTROPHIL PROTEIN RELATED TO THE S100 FAMILY [J].

GUIGNARD, F ;

MAUEL, J ;

MARKERT, M .

BIOCHEMICAL JOURNAL, 1995, 309 :395-401

[10] S100A2 level changes are related to human periodontitis [J].

Heo, Sun-Hee ;

Choi, Young-Jin ;

Lee, Ji-Hyun ;

Lee, Jae-Mok ;

Cho, Je-Yoel .

MOLECULES AND CELLS, 2011, 32 (05) :445-450

← 1 2 3 4 →