Prognostic value of D-dimer/fibrinogen ratio in the adverse outcomes of patients hospitalized for heart failure

被引：15

作者：

Zhao, Tian-Jun ^{[1
]}

Yang, Qian-Kun ^{[2
]}

Tan, Chun-Yu ^{[1
]}

Bi, Li-Dan ^{[1
]}

Li, Jie ^{[1
]}

Miao, Zhi-Lin ^{[1
]}

机构：

[1] China Med Univ, Peoples Hosp Liaoning Prov, Peoples Hosp, Dept Cardiol, Shenyang 110016, Peoples R China

[2] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Bone & Soft Tissue Surg, Shenyang 110042, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 18期

关键词：

D-dimer; fibrinogen ratio; fibrinogen; heart failure; prognosis; DISSEMINATED INTRAVASCULAR COAGULATION; REDUCED EJECTION FRACTION; RELATIVE LYMPHOCYTE COUNT; DIMER LEVELS PREDICT; RANDOMIZED-TRIAL; DIAGNOSIS; FIBRINOGEN; MORTALITY; WARFARIN; ASPIRIN;

D O I：

10.2217/bmm-2020-0553

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To evaluate the clinical value of plasma D-dimer/fibrinogen ratio (DFR) in patients hospitalized for heart failure (HF). Methods: Clinical data of 235 patients were retrospectively analyzed. Kaplan-Meier method and Cox regression analysis were used to identify significant prognosticators. Results: The Kaplan-Meier analysis showed that a higher DFR level was significantly associated with an increase in the end point outcomes, including HF readmission, thrombotic events and death (log-rank test: p < 0.001). The multivariate Cox regression analysis showed that the high tertile of DFR was significantly associated with the study end points (HR: 2.18; 95% CI: 1.31-3.62; p = 0.003), compared with the low tertile. Conclusion: DFR is a reliable prognostic indicator for patients hospitalized for HF.

引用

页码：1733 / 1745

页数：13

共 60 条

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