CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy

被引：114

作者：

Chen, Nan ^{[1
,2
]}

Morello, Aurore ^{[1
,2
]}

Tano, Zachary ^{[2
]}

Adusumilli, Prasad S. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Serv, New York, NY 10021 USA

来源：

ONCOIMMUNOLOGY | 2017年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Adoptive T-cell therapy; breast cancer; immunosuppression; lung cancer; mesothelioma; PD-1; blockade; tumor microenvironment;

D O I：

10.1080/2162402X.2016.1273302

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors.

引用

页数：3

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