Incorporating placental tissue in cord blood banking for stem cell transplantation

被引：6

作者：

Teofili, Luciana ^{[1
]}

Silini, Antonietta R. ^{[2
]}

Bianchi, Maria ^{[3
]}

Valentini, Caterina Giovanna ^{[3
]}

Parolini, Ornella ^{[2
,4
]}

机构：

[1] Univ Cattolica Sacro Cuore, Banca Sangue Cordone Ombelicale UNICATT, Policlin Univ A Gemelli IRCCS, Rome, Italy

[2] Ist Osped, Ctr Ric E Menni Fdn Poliambulanza, Brescia, Italy

[3] Banca Sangue Cordone Ombelicale UNICATT, Policlin Univ A Gemelli IRCCS, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Fac Med & Chirurg A Gemelli, Ist Anat Umana & Biol Cellulare, Rome, Italy

来源：

EXPERT REVIEW OF HEMATOLOGY | 2018年 / 11卷 / 08期

关键词：

Hematopoietic stem cells; individualized therapy; mesenchymal stem; stromal cells; personalized medicine; placenta; regenerative medicine; umbilical blood; MESENCHYMAL STROMAL CELLS; AMNION EPITHELIAL-CELLS; COLONY-FORMING CELLS; REGULATORY T-CELLS; MEMBRANE-DERIVED CELLS; CHORIONIC VILLI; REGENERATIVE THERAPY; FUNCTIONAL RECOVERY; CONDITIONED MEDIUM; PERIPHERAL-BLOOD;

D O I：

10.1080/17474086.2018.1483717

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Human term placenta is comprised of various tissues from which different cells can be obtained, including hematopoietic stem cells and mesenchymal stem/stromal cells (MSCs).Areas covered: This review will discuss the possibility to incorporate placental tissue cells in cord blood banking. It will discuss general features of human placenta, with a brief review of the immune cells at the fetal-maternal interface and the different cell populations isolated from placenta, with a particular focus on MSCs. It will address the question as to why placenta-derived MSCs should be banked with their hematopoietic counterparts. It will discuss clinical trials which are studying safety and efficacy of placenta tissue-derived MSCs in selected diseases, and preclinical studies which have proven their therapeutic properties in other diseases. It will discuss banking of umbilical cord blood and raise several issues for improvement, and the applications of cord blood cells in non-malignant disorders.Expert commentary: Umbilical cord blood banking saves lives worldwide. The concomitant banking of non-hematopoietic cells from placenta, which could be applied therapeutically in the future, alone or in combination to their hematopoietic counterparts, could exploit current banking processes while laying the foundation for clinical trials exploring placenta-derived cell therapies in regenerative medicine.

引用

页码：649 / 661

页数：13

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