Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery

被引：28

作者：

Andrea, Kori A. ^{[1
]}

Wang, Li ^{[3
]}

Carrier, Andrew J. ^{[2
]}

Campbell, Melanie ^{[1
]}

Buhariwalla, Margaret ^{[4
]}

Mutch, MacKenzi ^{[1
]}

MacQuarrie, Stephanie L. ^{[2
]}

Bennett, Craig ^{[4
]}

Mkandawire, Martin ^{[1
]}

Oakes, Ken ^{[1
]}

Lu, Mingsheng ^{[5
]}

Zhang, Xu ^{[1
]}

机构：

[1] Cape Breton Univ, Verschuren Ctr Sustainabil Energy & Environm, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[2] Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[3] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310018, Zhejiang, Peoples R China

[4] Acad Univ, Dept Phys, Wolfville, NS B4P 2R6, Canada

[5] Huaihai Inst Technol, Coll Marine Life & Fisheries, Lianyungang 222005, Jiang Su, Peoples R China

来源：

LANGMUIR | 2017年 / 33卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

DRUG-DELIVERY; GOLD NANOPARTICLES; CANCER-THERAPY; POLYETHYLENE-GLYCOL; INTERCALATION; NANOHYBRIDS; SYSTEMS; SIRNA; OLIGONUCLEOTIDES; SPECTROSCOPY;

D O I：

10.1021/acs.langmuir.6b04172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnesium aluminum-layered double-hydroxide nanoparticles (LDH NPs) are promising drug-delivery vehicles for gene therapy, particularly for siRNA interference; however, the interactions between oligo-DNA and LDH surfaces have not been adequately elucidated. Through a mechanistic study, oligo-DNA initially appears to rapidly bind strongly to the LDH outer surfaces through interactions with their phosphate backbones via ligand exchange with OH- on Mg2+ centers and electrostatic forces with Al3+. These initial interactions might precede diffusion into interlayer spaces, and this knowledge can be used to design better gene therapy delivery systems.

引用

页码：3926 / 3933

页数：8

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