Regio- and stereoselective synthesis of vicinal fluorohydrins

被引：54

作者：

Haufe, G ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2004年 / 125卷 / 06期

关键词：

condensation; enzyme-catalysis; epoxides; fluorohydrins; fluoroketones; hydrofluorination; reduction; resolution; ring opening; stereoselectivity; synthesis;

D O I：

10.1016/j.jfluchem.2004.01.023

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Vicinal fluorohydrins are useful building blocks as well as important targets for synthesis of bioactive compounds or new materials. This review gives an overview on regio- and stereoselective, particularly enantioselective, syntheses of such compounds by building block methods, reduction of alpha-fluoro carbonyl compounds and ring opening of epoxides with hydrofluorinating reagents. Resolution of racemic vicinal fluorohydrins using enzyme-catalyzed reactions will also be discussed in detail. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：875 / 894

页数：20

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