Fractalkine Receptor/Ligand Genetic Variants and Carotid Intima-Media Thickness

被引：10
作者：
Debette, Stephanie [1 ,2 ,3 ]
Bevan, Steve [1 ]
Dartigues, Jean-Francois [4 ]
Sitzer, Matthias [6 ]
Lorenz, Matthias [6 ]
Ducimetiere, Pierre [5 ]
Amouyel, Philippe [3 ]
Markus, Hugh S. [1 ]
机构：
[1] St Georges Univ London, London, England
[2] Lille Univ Hosp, Dept Neurol, EA2691, Lille, France
[3] Inst Pasteur, INSERM, U744, F-59019 Lille, France
[4] INSERM, U593, Bordeaux, France
[5] INSERM, U909, Paris, France
[6] Univ Frankfurt, Dept Neurol, Frankfurt, Germany
来源：
STROKE | 2009年 / 40卷 / 06期
关键词：
atherosclerosis; carotid intimal medial thickness; carotid ultrasound; epidemiology; genetics; risk factors; ultrasound; carotid artery; ATHEROSCLEROSIS; ASSOCIATION; PLAQUES; RISK;
D O I：
10.1161/STROKEAHA.108.537159
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and Purpose-The fractalkine ligand/receptor (CX3CL1/CX3CR1) complex is important in inflammatory responses and has been associated with vascular disease. We determined whether genetic variants in CX3CL1 and CX3CR1 are associated with carotid atherosclerosis in 2 large European populations. Methods-18 polymorphisms in CX3CL1 and CX3CR1 were genotyped in 2763 German community individuals (CAPS). Positive results were tested for replication on 6049 French community individuals (3C Study). Results-In CAPS we found associations of common carotid artery (CCA)-IMT with 2 CX3CL1 (rs170364, rs614230) and 1 CX3CR1 (rs3732378) variants, and significant interactions of CX3CR1 rs11129820, rs3732378, and rs614230 variants with smoking and alcohol consumption in relation with CCA-IMT. None of these were replicated in 3C. In 3C only there was a borderline significant association of rs3732378 with carotid plaques. Conclusion-In almost 9000 subjects, we found no replicable associations of CX3CL1 and CX3CR1 polymorphisms with CCA-IMT or plaque. (Stroke. 2009; 40: 2212-2214.)
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收藏
页码：2212 / 2214
页数：3
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