Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides

被引：53

作者：

Gao, Feng ^{[1
,2
]}

Kim, Byeong-Seon ^{[2
]}

Walsh, Patrick J. ^{[2
]}

机构：

[1] Sichuan Agr Univ, Agron Coll, Dept Med Plants, Chengdu 611130, Peoples R China

[2] Univ Penn, Dept Chem, Penn Merck Lab High Throughput Experimentat, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 73期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

C-H BOND; DIRECT ALPHA-ARYLATION; OXAZOLE; AZOLES; MECHANISM; FUNCTIONALIZATION; IODOBENZENE; BENZOAZOLES; SULFOXIDES; CHLORIDES;

D O I：

10.1039/c4cc05307a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl bromides is presented. The Pd(OAc)(2)/NiXantphos-based catalyst enables the introduction of various aryl and heteroaryl groups, via a deprotonative cross-coupling process (DCCP) in good to excellent yields (60-99%).

引用

页码：10661 / 10664

页数：4

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