Model Lipid Membranes on a Tunable Polymer Cushion

被引：47

作者：

Smith, Hillary L. ^{[1
]}

Jablin, Michael S. ^{[1
]}

Vidyasagar, Ajay ^{[2
]}

Saiz, Jessica ^{[1
]}

Watkins, Erik ^{[1
,3
]}

Toomey, Ryan ^{[2
]}

Hurd, Alan J. ^{[1
]}

Majewski, Jaroslaw ^{[1
]}

机构：

[1] Los Alamos Natl Lab, Manuel Lujan Jr Neutron Scattering Ctr, Los Alamos, NM 87545 USA

[2] Univ S Florida, Dept Chem & Biomed Engn, Tampa, FL 33620 USA

[3] Univ Calif Davis, Biophys Grad Grp, Davis, CA 95616 USA

来源：

PHYSICAL REVIEW LETTERS | 2009年 / 102卷 / 22期

基金：

美国国家科学基金会;

关键词：

NEUTRON-SCATTERING; DYNAMICS; SURFACES; GEL;

D O I：

10.1103/PhysRevLett.102.228102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

A hydrated, surface-tethered polymer network capable of fivefold change in thickness over a 25-37 degrees C temperature range has been demonstrated via neutron reflectivity and fluorescence microscopy to be a novel support for single lipid bilayers in a liquid environment. As the polymer swells from 170 to 900 A, it promotes both in- and out-of-plane fluctuations of the supported membrane. The cushioned bilayer proved to be very robust, remaining structurally intact for 16 days and many temperature cycles. The promotion of membrane fluctuations offers far-reaching applications for this system as a surrogate biomembrane.

引用

页数：4

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