Fractalkine and placental growth factor: A duet of inflammation and angiogenesis in cardiovascular disorders

被引：26
|
作者：
Skoda, Marta [1 ]
Stangret, Aleksandra [1 ]
Szukiewicz, Dariusz [1 ]
机构：
[1] Med Univ Warsaw, Dept Gen & Expt Pathol, CEPT Lab, Ul Pawinskiego 3C, PL-02106 Warsaw, Poland
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2018年 / 39卷
关键词：
Fractalkine; PlGF; Inflammation; Angiogenesis; Atherosclerosis; NF-KAPPA-B; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS; ATHEROSCLEROTIC PLAQUES; GENOMIC ORGANIZATION; FACTOR EXPRESSION; IMMUNE-RESPONSE; RECEPTOR CX3CR1; STEM-CELLS; FACTOR-I;
D O I：
10.1016/j.cytogfr.2017.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation and angiogenesis are two interdependent processes underlying pathogenesis of cardiovascular disorders. The initiation and progression of atherosclerosis strongly depends on specific patterns of cytokine expression. In this review, we analyze correlation between expression of two members of the cytokine family and the processes of inflammation and angiogenesis related to atherosclerosis. Placental growth factor and chemokine CX3XL1 (fractalkine) promote inflammatory cell infiltration, angiogenesis and plaque rupture. Because these cytokines share similar roles during atherosclerotic development, their combined value as a predictor or indicator of inflammation and vascular healing may be extremely useful.
引用
收藏
页码：116 / 123
页数：8
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