Copper Catalyzed Oxidative Arylation of Tertiary Carbon Centers

被引：13

作者：

Basnet, Prakash ^{[1
]}

Sebold, Melissa B. ^{[1
]}

Hendrick, Charles E. ^{[1
]}

Kozlowski, Marisa C. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 24期

关键词：

C-H BONDS; CHEMOSELECTIVE ACTIVATION; QUATERNARY STEREOCENTERS; IMINONITRILES; DIMERS; SP(3);

D O I：

10.1021/acs.orglett.0c03581

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe herein a Cu(OTf)(2) catalyzed oxidative arylation of a tertiary carbon-containing substrate including aryl malononitriles, 3-aryl benzofuran-2-ones, and 3-aryl oxindoles. In some cases, the nitrile groups of the aryl malononitriles undergo further reactions leading to lactones or imines. These reaction conditions are applicable for a range of arenes, including phenols, anilines, anisoles, and heteroarenes. Mechanistic studies support the formation of a cationic intermediate via a two-electron oxidation.

引用

页码：9524 / 9528

页数：5

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