Zinc phthalocyanine-based water-soluble thiolated photosensitizer and its conjugates with gold nanoparticles: Synthesis and spectral properties

被引：4

作者：

Dement'eva, O. V. ^{[1
]}

Vinogradova, M. M. ^{[1
,2
]}

Luk'yanets, E. A. ^{[3
]}

Solov'eva, L. I. ^{[3
]}

Ogarev, V. A. ^{[1
]}

Rudoy, V. M. ^{[1
]}

机构：

[1] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia

[2] Mendeleev Univ Chem Technol, Russian Acad Sci, Higher Chem Coll, Moscow 125047, Russia

[3] Res Inst Organ Intermediates & Dyes, State Sci Ctr, Moscow 123995, Russia

来源：

COLLOID JOURNAL | 2014年 / 76卷 / 05期

关键词：

PHOTODYNAMIC THERAPY; ENERGY-TRANSFER; SINGLET OXYGEN; PARTICLE-SIZE; GENERATION; DEPENDENCE; DISTANCE;

D O I：

10.1134/S1061933X14050068

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new photosensitizer, monoconjugate of zinc octa-4,5-carboxy-phthalocyanine with L-cysteine, which is rather readily soluble in water, has been synthesized and characterized. The chemisorption of its molecules on the surface of gold nanoparticles with different sizes has been studied. A comparative analysis of the spectral characteristics of the synthesized conjugates of gold nanoparticles with the photosensitizer has shown that the photosensitizer grafted to gold nanoparticles exhibits rather intense fluorescence. Therefore, such conjugates can be used for photodynamic therapy of tumors.

引用

页码：539 / 545

页数：7

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