Dark-field Microspectroscopic Analysis of Gold Nanorods in Spiral Ganglion Neurons

被引：0

作者：

Yong, J. ^{[1
]}

Brown, W. G. A. ^{[2
]}

Needham, K. ^{[3
]}

Nayagam, B. A. ^{[4
]}

Yu, A. ^{[1
]}

McArthur, S. L. ^{[2
]}

Stoddart, P. R. ^{[2
]}

机构：

[1] Swinburne Univ Technol, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia

[2] Swinburne Univ Technol, Fac Engn & Ind Sci, Hawthorn, Vic 3122, Australia

[3] Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Dep Audiol & Speech Pathol, Melbourne, Vic 3010, Australia

来源：

MICRO/NANO MATERIALS, DEVICES, AND SYSTEMS | 2013年 / 8923卷

关键词：

Dark-field imaging; gold nanorods; microspectroscopy; neural stimulation; PHOTOTHERMAL THERAPY; GENE-EXPRESSION; NANOPARTICLES; ABSORPTION; RELEASE; GROWTH; SHAPE; SIZE; DNA; STIMULATION;

D O I：

10.1117/12.2033767

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Heterogeneous samples of spiral ganglion neuron primary cells were incubated with gold nanorods in order to investigate the photothermal processes induced by exposure to 780 nm laser light. Dark-field microspectroscopy was used to analyze the distribution and spectrum of nanorods in the neurons. The scattering data showed a typical gold nanorod spectrum, while a shift in the peak position suggested changes in the refractive index of the nanorod environment. The relationship between gold nanorods distribution and local temperature has also been examined with an open pipette microelectrode placed in the surrounding bath of the neurons. These temperature measurements confirm that the gold nanorods provide efficient localized heating under 780 nm laser exposure.

引用

页数：9

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