Recent advances in genome editing and creation of genetically modified pigs

被引：40

作者：

Butler, James R. ^{[1
]}

Ladowski, Joseph M. ^{[1
]}

Martens, Gregory R. ^{[1
]}

Tector, Matthew ^{[1
]}

Tector, A. Joseph ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Surg, Indianapolis, IN 46202 USA

来源：

INTERNATIONAL JOURNAL OF SURGERY | 2015年 / 23卷

关键词：

Homologous recombination; Zinc finger nuclease; TALEN CRISPR/Cas9; Endonuclease; Off-target; TRANSGENIC PIGS; NUCLEAR TRANSFER; KNOCKOUT PIGS; EXPRESSION; RNA; GENE; CAS9; ALPHA-1,2-FUCOSYL-TRANSFERASE; GALACTOSIDASE; GENERATION;

D O I：

10.1016/j.ijsu.2015.07.684

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The field of xenotransplantation is benefiting greatly from recent advances in genetic engineering. The efficiency and pace with which new model animals are being created has dramatically sped progress towards clinical relevance. Endonuclease-driven genome editing now allows for the efficient generation of targeted genetic alterations. Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

引用

页码：217 / 222

页数：6

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