Controling stem cell proliferation - CKIs at work

被引：6
作者：
Bruggeman, Sophia W. M. [1 ]
van Lohuizen, Maarten [1 ]
机构：
[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands
来源：
CELL CYCLE | 2006年 / 5卷 / 12期
关键词：
CKI; adult stem cells; self-renewal; polycomb group; Bmi1;
D O I：
10.4161/cc.5.12.2806
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.
引用
收藏
页码：1281 / 1285
页数：5
相关论文
共 70 条
[1]   ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage [J].
Aladjem, MI ;
Spike, BT ;
Rodewald, LW ;
Hope, TJ ;
Klemm, M ;
Jaenisch, R ;
Wahl, GM .
CURRENT BIOLOGY, 1998, 8 (03) :145-155
[2]   Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells [J].
Betschinger, J ;
Mechtler, K ;
Knoblich, JA .
CELL, 2006, 124 (06) :1241-1253
[3]   Dare to be different:: Asymmetric cell division in Drosophila, C-elegans and vertebrates [J].
Betschinger, J ;
Knoblich, JA .
CURRENT BIOLOGY, 2004, 14 (16) :R674-R685
[4]   Oncogene-induced senescence as an initial barrier in lymphoma development [J].
Braig, M ;
Lee, S ;
Loddenkemper, C ;
Rudolph, C ;
Peters, AHFM ;
Schlegelberger, B ;
Stein, H ;
Dörken, B ;
Jenuwein, T ;
Schmitt, CA .
NATURE, 2005, 436 (7051) :660-665
[5]   Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice [J].
Bruggeman, SWM ;
Valk-Lingbeek, ME ;
van der Stoop, PPM ;
Jacobs, JJL ;
Kieboom, K ;
Tanger, E ;
Hulsman, D ;
Leung, C ;
Arsenijevic, Y ;
Marino, S ;
van Lohuizen, M .
GENES & DEVELOPMENT, 2005, 19 (12) :1438-1443
[6]   Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors [J].
Campisi, J .
CELL, 2005, 120 (04) :513-522
[7]  
Casaccia-Bonnefil P, 1999, DEVELOPMENT, V126, P4027
[8]   Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27(Kip1) [J].
CasacciaBonnefil, P ;
Tikoo, R ;
Kiyokawa, H ;
Friedrich, V ;
Chao, MV ;
Koff, A .
GENES & DEVELOPMENT, 1997, 11 (18) :2335-2346
[9]   Asymmetric segregation of numb in retinal development and the influence of the pigmented epithelium [J].
Cayouette, M ;
Whitmore, AV ;
Jeffery, G ;
Raff, M .
JOURNAL OF NEUROSCIENCE, 2001, 21 (15) :5643-5651
[10]   Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells [J].
Chambers, I ;
Colby, D ;
Robertson, M ;
Nichols, J ;
Lee, S ;
Tweedie, S ;
Smith, A .
CELL, 2003, 113 (05) :643-655
1234567