HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases

被引：21
|
作者：
Li, Ruo-Lan [1 ]
He, Li-Ying [1 ]
Zhang, Qing [1 ]
Liu, Jia [1 ]
Lu, Feng [1 ]
Duan, Hu-Xin-Yue [1 ]
Fan, Lin-Hong [1 ]
Peng, Wei [1 ]
Huang, Yong-Liang [2 ]
Wu, Chun-Jie [1 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
[2] Hosp Chengdu Univ Tradit Chinese Med, Pharm Dept, Chengdu 610072, Sichuan, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2020年 / 14卷
基金：
中国国家自然科学基金;
关键词：
HIF-1; alpha; disease; natural medicine; traditional Chinese medicine; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTOR-1; RIBOSOME ENTRY SITE; UP-REGULATION; FACTOR EXPRESSION; CANCER CELLS; TUMOR-SUPPRESSOR; DOWN-REGULATION; KAPPA-B;
D O I：
10.2147/DDDT.S274980
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
HIF-1 alpha is an important factor regulating oxygen balance in mammals, and its expression is closely related to various physiological and pathological conditions of the body. Because HIF-1 alpha plays an important role in the occurrence and development of cancer and other diseases, it has become an enduring research hotspot. At the same time, natural medicines and traditional Chinese medicine compounds have amazing curative effects in various diseases related to HIF-1 subtype due to their unique pharmacological effects and more effective ingredients. Therefore, in this article, we first outline the structure of HIF-1 alpha and the regulation related to its expression, then introduce various diseases closely related to HIF-1 alpha, and finally focus on the regulation of natural medicines and compound Chinese medicines through various pathways. This will help us understand HIF-1 alpha systematically, and use HIF-1 alpha as a target to discover more natural medicines and traditional Chinese medicines that can treat related diseases.
引用
收藏
页码：4915 / 4949
页数：35
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