Insights into the biological functions of Dock family guanine nucleotide exchange factors

被引：125

作者：

Laurin, Melanie ^{[1
,2
]}

Cote, Jean-Francois ^{[1
,2
,3
,4
]}

机构：

[1] Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

[2] Univ Montreal, Dept Med, Programmes Biol Mol, Montreal, PQ H3T 1J4, Canada

[3] Univ Montreal, Dept Biochim, Montreal, PQ H3T 1J4, Canada

[4] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 1A3, Canada

来源：

GENES & DEVELOPMENT | 2014年 / 28卷 / 06期

关键词：

mouse models; Dock180; Elmo; neurogenesis; myoblast fusion; migration; RAC ACTIVATOR; MYOBLAST FUSION; RHO GTPASES; MEMBRANE RECRUITMENT; AXONAL OUTGROWTH; APOPTOTIC CELLS; CDC42; ACTIVATOR; BREAST-CANCER; MOUSE MODELS; PROTEINS;

D O I：

10.1101/gad.236349.113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and migration. Two families of guanine nucleotide exchange factors (GEFs) found in metazoans, Dbl and Dock, are responsible for the spatiotemporal activation of Rac and Cdc42 proteins and their downstream signaling pathways. This review focuses on the emerging roles of the mammalian DOCK family in development and disease. We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies.

引用

页码：533 / 547

页数：15

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