Circular RNAs in cancer: an emerging key player

被引:239
作者
Dong, Yeping [1 ]
He, Dan [1 ]
Peng, Zhenzi [1 ]
Peng, Wei [1 ]
Shi, Wenwen [1 ]
Wang, Jun [1 ]
Li, Bin [1 ]
Zhang, Chunfang [2 ]
Duan, Chaojun [1 ,2 ,3 ]
机构
[1] Cent S Univ, Inst Med Sci, Xiangya Hosp, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Minist Hlth, Key Lab Canc Prote Chinese, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Dept Thorac Surg, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China
来源
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷
关键词
Circular RNAs; Cancer; MicroRNA sponges; Biomarkers; GROWTH-FACTOR RECEPTOR; MESSENGER-RNA; MICRORNA-7; EXPRESSION; BIOMARKER; BIOGENESIS; PATHWAY; TRANSLATION; PLATELETS; REVEALS;
D O I
10.1186/s13045-016-0370-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles in cancer.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 50 条
[41]   Translation and functional roles of circular RNAs in human cancer [J].
Lei, Ming ;
Zheng, Guantao ;
Ning, Qianqian ;
Zheng, Junnian ;
Dong, Dong .
MOLECULAR CANCER, 2020, 19 (01)
[42]   Circular RNAs as potential biomarkers for cancer diagnosis and therapy [J].
Wang, Fengling ;
Nazarali, Adil J. ;
Ji, Shaoping .
AMERICAN JOURNAL OF CANCER RESEARCH, 2016, 6 (06) :1167-1176
[43]   The Emerging Role of Circular RNAs in Alzheimer's Disease and Parkinson's Disease [J].
Zhang, Meng ;
Bian, Zhigang .
FRONTIERS IN AGING NEUROSCIENCE, 2021, 13
[44]   Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance [J].
Wang, Xiaolin ;
Zhang, Jiahui ;
Cao, Guozhen ;
Hua, Jinghan ;
Shan, Ge ;
Lin, Wenchu .
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)
[45]   Circular RNA involvement in aging: An emerging player with great potential [J].
Cai, Hongcai ;
Li, Yamin ;
Niringiyumukiza, Jean Damascene ;
Su, Ping ;
Xiang, Wenpei .
MECHANISMS OF AGEING AND DEVELOPMENT, 2019, 178 :16-24
[46]   The emerging landscape of circular RNA in cardiovascular diseases [J].
Zhou, Meng-yuan ;
Yang, Jin-Ming ;
Xiong, Xing-dong .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2018, 122 :134-139
[47]   Circular RNAs and their emerging roles as diagnostic and prognostic biomarkers in ovarian cancer [J].
Sheng, Rong ;
Li, Xiaoduan ;
Wang, Ziliang ;
Wang, Xipeng .
CANCER LETTERS, 2020, 473 :139-147
[48]   An Emerging Role for Circular RNAs in Osteoarthritis [J].
Yu, Chen-Xi ;
Sun, Shui .
YONSEI MEDICAL JOURNAL, 2018, 59 (03) :349-355
[49]   Emerging Epigenetic Regulation of Circular RNAs in Human Cancer [J].
Wu, Jie ;
Qi, Xiaoqian ;
Liu, Lina ;
Hu, Xin ;
Liu, Jingwen ;
Yang, Jianming ;
Yang, Jun ;
Lu, Lu ;
Zhang, Zheng ;
Ma, Shiqing ;
Li, Hongfa ;
Yun, Xinyue ;
Sun, Tong ;
Wang, Yue ;
Wang, Zuomin ;
Liu, Zihao ;
Zhao, Wei .
MOLECULAR THERAPY-NUCLEIC ACIDS, 2019, 16 :589-596
[50]   The Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer [J].
Wang, Man ;
Yu, Fei ;
Zhang, Yuan ;
Zhang, Lei ;
Chang, Wenguang ;
Wang, Kun .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10