Circular RNAs in cancer: an emerging key player

被引：239

作者：

Dong, Yeping ^{[1
]}

He, Dan ^{[1
]}

Peng, Zhenzi ^{[1
]}

Peng, Wei ^{[1
]}

Shi, Wenwen ^{[1
]}

Wang, Jun ^{[1
]}

Li, Bin ^{[1
]}

Zhang, Chunfang ^{[2
]}

Duan, Chaojun ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Inst Med Sci, Xiangya Hosp, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Minist Hlth, Key Lab Canc Prote Chinese, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp, Dept Thorac Surg, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷

关键词：

Circular RNAs; Cancer; MicroRNA sponges; Biomarkers; GROWTH-FACTOR RECEPTOR; MESSENGER-RNA; MICRORNA-7; EXPRESSION; BIOMARKER; BIOGENESIS; PATHWAY; TRANSLATION; PLATELETS; REVEALS;

D O I：

10.1186/s13045-016-0370-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles in cancer.

引用

页码：1 / 8

页数：8

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