Immune response following infection withSARS-CoV-2 and other coronaviruses: A rapid review

被引:72
作者
Murchu, Eamon O. [1 ,2 ]
Byrne, Paula [1 ]
Walsh, Kieran A. [1 ]
Carty, Paul G. [1 ]
Connolly, Maire [3 ]
De Gascun, Cillian [4 ]
Jordan, Karen [1 ]
Keoghan, Mary [5 ]
O'Brien, Kirsty K. [1 ]
O'Neill, Michelle [1 ]
Smith, Susan M. [6 ]
Teljeur, Conor [1 ]
Ryan, Mairin [1 ,7 ]
Harrington, Patricia [1 ]
机构
[1] Hlth Informat & Qual Author, Hlth Technol Assessment Directorate, Dublin 7, Ireland
[2] Trinity Coll Dublin, Ctr Hlth Policy & Management, Dublin 2, Ireland
[3] Natl Univ Ireland Galway, Sch Med, Galway, Ireland
[4] Univ Coll Dublin, UCD Natl Virus Reference Lab, Dublin 4, Ireland
[5] Beaumont Hosp, Dept Clin Immunol, Dublin 9, Ireland
[6] Royal Coll Surgeons Ireland, Dept Gen Practice, Hlth Res Board Ctr Primary Care Res, Dublin 2, Ireland
[7] Trinity Coll Dublin, Dept Pharmacol & Therapeut, Trinity Hlth Sci, Dublin 8, Ireland
关键词
COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; seasonal coronaviruses; ACUTE RESPIRATORY SYNDROME; SYNDROME SARS CORONAVIRUS; T-LYMPHOCYTE RESPONSES; ANTIBODY-RESPONSES; CELL RESPONSES; SARS-COV-2; COVID-19; PROFILE; IGG; NEUTRALIZATION;
D O I
10.1002/rmv.2162
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In this review, we systematically searched and summarized the evidence on the immune response and reinfection rate following SARS-CoV-2 infection. We also retrieved studies on SARS-CoV and MERS-CoV to assess the long-term duration of antibody responses. A protocol based on Cochrane rapid review methodology was adhered to and databases were searched from 1/1/2000 until 26/5/2020. Of 4744 citations retrieved, 102 studies met our inclusion criteria. Seventy-four studies were retrieved on SARS-CoV-2. While the rate and timing of IgM and IgG seroconversion were inconsistent across studies, most seroconverted for IgG within 2 weeks and 100% (N = 62) within 4 weeks. IgG was still detected at the end of follow-up (49-65 days) in all patients (N = 24). Neutralizing antibodies were detected in 92%-100% of patients (up to 53 days). It is not clear if reinfection with SARS-CoV-2 is possible, with studies more suggestive of intermittent detection of residual RNA. Twenty-five studies were retrieved on SARS-CoV. In general, SARS-CoV-specific IgG was maintained for 1-2 years post-infection and declined thereafter, although one study detected IgG up to 12 years post-infection. Neutralizing antibodies were detected up to 17 years in another study. Three studies on MERS-CoV reported that IgG may be detected up to 2 years. In conclusion, limited early data suggest that most patients seroconvert for SARS-CoV-2-specific IgG within 2 weeks. While the long-term duration of antibody responses is unknown, evidence from SARS-CoV studies suggest SARS-CoV-specific IgG is sustained for 1-2 years and declines thereafter.
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页数:11
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