Fagomine isomers and glycosides from Xanthocercis zambesiaca

被引：80

作者：

Kato, A

Asano, N

Kizu, H

Matsui, K

Watson, AA

Nash, RJ

机构：

[1] HOKURIKU UNIV,FAC PHARMACEUT SCI,KANAZAWA,ISHIKAWA 92011,JAPAN

[2] AFRC,INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,CARDIGAN,WALES

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 03期

关键词：

D O I：

10.1021/np960646y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

50% aqueous MeOH extracts from the leaves and roots of Xanthocercis zambesiaca (Leguminosae) were subjected to various ion-exchange column chromatographic steps to give fagomine (1), 3-epi-fagomine (2), 3,4-di-epi-fagomine (3), 3-O-beta-D-glucopyranosylfagomine (4), and 4-0-beta-D-glucopyranosylfagomine (5). Their structures were determined by spectroscopic analyses, particularly by extensive 1D and 2D NMR studies. Compounds 3 and 4 are new natural products. Compound 1 is a good inhibitor of isomaltase and certain alpha- and beta-galactosidases. Whereas 2 is a more potent inhibitor of isomaltase and beta-galactosidases than 1, it does not inhibit alpha-galactosidase. Compounds 3-5 exhibited no significant inhibition against the glycosidases used.

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页码：312 / 314

页数：3

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