Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors

被引：22

作者：

Yahiaoui, S

Pouget, C

Fagnere, C

Champavier, Y

Habrioux, G

Chulia, AJ

机构：

[1] Fac Pharm, UPRES EA 1085, F-87025 Limoges, France

[2] Univ Limoges, RMN, Serv Commun, Fac Pharm, F-87025 Limoges, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

4-triazolylflavans; aromatase inhibition; breast cancer;

D O I：

10.1016/j.bmcl.2004.07.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：5215 / 5218

页数：4

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