Ear lobe crease: a marker of coronary artery disease?

被引：22
作者：
Agouridis, Aris P. [1 ,2 ]
Elisaf, Moses S. [1 ]
Nair, Devaki R. [2 ]
Mikhailidis, Dimitri P. [3 ]
机构：
[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece
[2] Royal Free London Fdn Trust, Dept Clin Biochem Vasc Dis Prevent Clin, London, England
[3] UCL, Dept Clin Biochem Vasc Dis Prevent Clin, Sch Med, London NW3 2QG, England
来源：
ARCHIVES OF MEDICAL SCIENCE | 2015年 / 11卷 / 06期
关键词：
ear lobe crease; coronary artery disease; Frank's sign; DIAGONAL EARLOBE CREASE; FATAL CARDIOVASCULAR-DISEASE; ACUTE MYOCARDIAL-INFARCTION; RISK-FACTORS; MEDICAL LITERATURE; DIAMOND-FORRESTER; PREDICTIVE-VALUE; HEART-DISEASE; FRANKS SIGN; ALL-CAUSE;
D O I：
10.5114/aoms.2015.56340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The ear lobe crease (ELC) has been defined as a deep wrinkle that extends backwards from the tragus to the auricle. It has been proposed that ELC is a predictor of coronary artery disease (CAD). In this review, we consider the possible association between ELC and CAD. Our aim is to systematically address all the relevant evidence in this field. There are many studies that support an association between ELC and CAD. However, other studies did not find such an association. A recent meta-analysis supports the hypothesis that ELC could be a marker of CAD. However, several limitations raise doubts as to whether we should accept this link.
引用
收藏
页码：1145 / 1155
页数：11
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