Ear lobe crease: a marker of coronary artery disease?

被引：23

作者：

Agouridis, Aris P. ^{[1
,2
]}

Elisaf, Moses S. ^{[1
]}

Nair, Devaki R. ^{[2
]}

Mikhailidis, Dimitri P. ^{[3
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece

[2] Royal Free London Fdn Trust, Dept Clin Biochem Vasc Dis Prevent Clin, London, England

[3] UCL, Dept Clin Biochem Vasc Dis Prevent Clin, Sch Med, London NW3 2QG, England

来源：

ARCHIVES OF MEDICAL SCIENCE | 2015年 / 11卷 / 06期

关键词：

ear lobe crease; coronary artery disease; Frank's sign; DIAGONAL EARLOBE CREASE; FATAL CARDIOVASCULAR-DISEASE; ACUTE MYOCARDIAL-INFARCTION; RISK-FACTORS; MEDICAL LITERATURE; DIAMOND-FORRESTER; PREDICTIVE-VALUE; HEART-DISEASE; FRANKS SIGN; ALL-CAUSE;

D O I：

10.5114/aoms.2015.56340

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ear lobe crease (ELC) has been defined as a deep wrinkle that extends backwards from the tragus to the auricle. It has been proposed that ELC is a predictor of coronary artery disease (CAD). In this review, we consider the possible association between ELC and CAD. Our aim is to systematically address all the relevant evidence in this field. There are many studies that support an association between ELC and CAD. However, other studies did not find such an association. A recent meta-analysis supports the hypothesis that ELC could be a marker of CAD. However, several limitations raise doubts as to whether we should accept this link.

引用

页码：1145 / 1155

页数：11

共 122 条

[1]

ANDRESEN AR, 1976, NEW ENGL J MED, V294, P1182

[2] Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the Prospective Cardiovascular Munster (PROCAM) study [J].

Assmann, G ;

Cullen, P ;

Schulte, H .

CIRCULATION, 2002, 105 (03) :310-315

[3] Do we need to consider inflammatory markers when we treat atherosclerotic disease? [J].

Athyros, Vasilios G. ;

Kakafika, Anna I. ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

ATHEROSCLEROSIS, 2008, 200 (01) :1-12

[4] Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study [J].

Athyros, Vasilios G. ;

Katsiki, Niki ;

Tziomalos, Konstantinos ;

Gossios, Thomas D. ;

Theocharidou, Eleni ;

Gkaliagkousi, Eygenia ;

Anagnostis, Panagiotis ;

Pagourelias, Efstathios D. ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

ARCHIVES OF MEDICAL SCIENCE, 2013, 9 (03) :418-426

[5]

Bahcelioglu M, 2005, SAUDI MED J, V26, P947

[6]

Berthold HK, 2011, CURR PHARM DESIGN, V17, P877

[7] A NEW WRINKLE TO THE EARLOBE CREASE [J].

BRADY, PM ;

ZIVE, MA ;

GOLDBERG, RJ ;

GORE, JM ;

DALEN, JE .

ARCHIVES OF INTERNAL MEDICINE, 1987, 147 (01) :65-66

[8]

BRUMFIELD DT, 1984, WESTERN J MED, V140, P793

[9]

BURTON JL, 1979, LANCET, V1, P328

[10] Diagonal ear-lobe crease is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease [J].

Celik, Sukru ;

Erdogan, Turan ;

Gedikli, Omer ;

Kiris, Abdulkadir ;

Erem, Cihangir .

ATHEROSCLEROSIS, 2007, 192 (02) :428-431

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