An Experience of Donor Lymphocyte Infusion after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease

被引：0
|
作者：
Rostami, Tahereh [1 ]
Kiumarsi, Azadeh [1 ]
机构：
[1] Shariati Hosp, Hematol Oncol & Stem Cell Transplantat Res Inst, Tehran 1411713131, Iran
来源：
PEDIATRIC REPORTS | 2020年 / 12卷 / 03期
关键词：
donor lymphocyte infusion; reduced-intensity conditioning; allogeneic hematopoietic stem cell transplantation; chronic granulomatous disease; CGD; BONE-MARROW-TRANSPLANTATION; VS-HOST DISEASE; CHIMERAS; TOXICITY; RISK;
D O I：
10.3390/pediatric12030030
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Allogeneic hematopoietic stem-cell transplantation is a well-known curative treatment for patients with chronic granulomatous disease. We present our experiment regarding ten patients with chronic granulomatous disease who underwent a reduced intensity conditioning regimen consisting of melfalan, fludarabine, and antithymocyte globulin. Donor lymphocyte infusion was used in three representative patients who developed mixed donor chimerism. After at least 2 years of median follow-up, 8 of the 10 patients are alive and well.
引用
收藏
页码：149 / 154
页数：6
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