Delivery of mRNA for regulating functions of immune cells

被引：35
作者：
Shi, Jia [1 ]
Huang, Meng-Wen [1 ]
Lu, Zi-Dong [2 ]
Du, Xiao-Jiao [2 ]
Shen, Song [1 ,3 ,4 ]
Xu, Cong-Fei [1 ,5 ,6 ]
Wang, Jun [1 ,7 ]
机构：
[1] South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 511442, Peoples R China
[2] South China Univ Technol, Sch Med, Guangzhou 510006, Peoples R China
[3] Shenzhen Bay Lab, Shenzhen 518132, Peoples R China
[4] South China Univ Technol, Key Lab Biomed Mat & Engn, Minist Educ, Guangzhou 510006, Peoples R China
[5] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China
[6] South China Univ Technol, Innovat Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
[7] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2022年 / 345卷
关键词：
mRNA; Drug delivery; Immune cells; Vaccine; Immunotherapy; ANTIGEN-PRESENTING CELLS; CONTROLS PHAGOSOMAL PH; DENDRITIC CELLS; IN-VIVO; T-CELLS; LIPID NANOPARTICLES; INTRACELLULAR DELIVERY; ANTITUMOR FUNCTIONS; ENDOSOMAL ESCAPE; HIV-1; INFECTION;
D O I：
10.1016/j.jconrel.2022.03.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Abnormal immune cell functions are commonly related to various diseases, including cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based therapy can regulate the functions of immune cells or assign new functions to immune cells, thereby generating therapeutic immune responses to treat these diseases. However, mRNA is unstable in physiological environments and can hardly enter the cytoplasm of target cells; thus, effective mRNA delivery systems are critical for developing mRNA therapy. The two mRNA vaccines of Pfizer-BioNTech and Moderna have demonstrated that lipid nanoparticles (LNPs) can deliver mRNA into dendritic cells (DCs) to induce immunization against severe acute respiratory syndrome coronavirus 2, which opened the floodgates to the development of mRNA therapy. Apart from DCs, other immune cells are promising targets for mRNA therapy. This review summarized the barriers to mRNA delivery and advances in mRNA delivery for regulating the functions of different immune cells.
引用
收藏
页码：494 / 511
页数：18
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