Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis

被引：59

作者：

Nguyen, Theresa H. ^{[1
]}

Morris, Scott A. ^{[1
]}

Zheng, Nan ^{[1
]}

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 13期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

alkynes; 3+2] annulation; cyclopropylanilines; diynes; enynes; intermolecular annulation; photocatalysis; visible light; PHOTOREDOX CATALYSIS; DEPROTECTION; COMPLEXES;

D O I：

10.1002/adsc.201400742

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One-step syntheses of carbocycles substituted with amines from simple starting materials remain rare. We recently developed an intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enables this one-step synthesis. Herein, we report our findings for a full-scale study of the annulation. Significant expansion of the substrate scope for both cyclopropylanilines and alkynes has been achieved. A range of structurally diverse carbocycles substituted with amines is prepared.

引用

页码：2831 / 2837

页数：7

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