Autoimmune Encephalitis in COVID-19 Infection: Our Experience and Systematic Review of the Literature

被引：28

作者：

Stoian, Adina ^{[1
,2
]}

Stoian, Mircea ^{[3
]}

Bajko, Zoltan ^{[2
,4
]}

Maier, Smaranda ^{[2
,4
]}

Andone, Sebastian ^{[2
]}

Cioflinc, Roxana Adriana ^{[2
]}

Motataianu, Anca ^{[2
,4
]}

Barcutean, Laura ^{[2
,4
]}

Balasa, Rodica ^{[2
,4
]}

机构：

[1] George Emil Palade Univ Med Pharm Sci & Technol T, Dept Pathophysiol, Targu Mures 540136, Romania

[2] Mures Cty Clin Emergency Hosp, Neurol Clin 1, Targu Mures 540136, Romania

[3] George Emil Palade Univ Med Pharm Sci & Technol T, Dept Anesthesiol & Crit Care Med, Targu Mures 540136, Romania

[4] George Emil Palade Univ Med Pharm Sci & Technol T, Dept Neurol, Targu Mures 540136, Romania

来源：

BIOMEDICINES | 2022年 / 10卷 / 04期

关键词：

COVID-19; infection; autoimmune encephalitis; voltage-gated potassium channels antibody; ACUTE RESPIRATORY SYNDROME; CONTACTIN-ASSOCIATED PROTEIN-2; NMDA RECEPTOR ENCEPHALITIS; CD8(+) T-CELLS; SYNDROME CORONAVIRUS; LUPUS-ERYTHEMATOSUS; MULTIPLE-SCLEROSIS; CLINICAL-MANIFESTATIONS; NERVOUS-SYSTEM; LEUCINE-RICH;

D O I：

10.3390/biomedicines10040774

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neurologic complications of COVID-19 infection are frequent in hospitalized patients; a high percentage of them present neurologic manifestations at some point during the course of their disease. Headache, muscle pain, encephalopathy and dizziness are among the most common complications. Encephalitis is an inflammatory condition with many etiologies. There are several forms of encephalitis associated with antibodies against intracellular neuronal proteins, cell surfaces or synaptic proteins, referred to as autoimmune encephalitis. Several case reports published in the literature document autoimmune encephalitis cases triggered by COVID-19 infection. Our paper first presents our experience in this issue and then systematically reviews the literature on autoimmune encephalitis that developed in the background of SARS-CoV-2 infections and also discusses the possible pathophysiological mechanisms of auto-immune-mediated damage to the nervous system. This review contributes to improve the management and prognosis of COVID-19-related autoimmune encephalitis.

引用

页数：32

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