MiR-155 controls follicular Treg cell-mediated humoral autoimmune intestinal injury by inhibiting CTLA-4 expression

被引：12

作者：

Chao, Gao ^{[1
]}

Li, Xiaoli ^{[2
]}

Ji, Yahong ^{[2
]}

Zhu, Ying ^{[2
]}

Li, Na ^{[2
]}

Zhang, Nana ^{[2
]}

Feng, Zunyong ^{[3
]}

Niu, Min ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Honghui Hosp, Dept Microsurg, Xian, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Honghui Hosp, Dept Gastroenterol, Youyi East Rd 555, Xian, Shaanxi, Peoples R China

[3] Warman Med Coll, Dept Forens Med, Wuhu, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2019年 / 71卷

基金：

中国国家自然科学基金;

关键词：

Follicular regulatory T cell; MIcroRNA-155; Foxp3; CTLA-4; IBD; MICRORNA-155; INFLAMMATION; SUPPRESSOR; RESPONSES;

D O I：

10.1016/j.intimp.2019.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High expression levels of miR-155 are involved in the pathogenesis of inflammatory bowel disease (IBD). We observed an increase in miR-155 in peripheral regulatory T (Treg) cells from IBD patients. Mice that specifically overexpress miR-155 in Foxp3+ Treg cells exhibit spontaneous autoimmunity and more severe dextran sulfate sodium (DSS)-induced intestinal injury. MiR-155 overexpression can lead to a lack of follicular Treg (Tfr) cells and central Treg (cTreg), whereas DSS treatment further depletes the Tfr cells. Furthermore, miR-155 can target the expression of CTLA-4 in cTreg and Tfr, directly inhibiting Tfr cell production and promoting enhanced germinal center (GC) B cell activation and autoantibody overproduction. This outcome may be the cause of severe intestinal injury in patients with autoimmune IBD.

引用

页码：267 / 276

页数：10

共 30 条

[1]

Chao G, BIOCH BIOPHYS RES CO

[2] Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism [J].

Chen, Siqi ;

Wang, Long ;

Fan, Jie ;

Ye, Cong ;

Dominguez, Donye ;

Zhang, Yi ;

Curiel, Tyler J. ;

Fang, Deyu ;

Kuzel, Timothy M. ;

Zhang, Bin .

CANCER RESEARCH, 2015, 75 (03) :519-531

[3] Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report [J].

Cicalese, Maria Pia ;

Gerosa, Jolanda ;

Baronio, Manuela ;

Montin, Davide ;

Licciardi, Francesco ;

Soresina, Annarosa ;

Dellepiane, Rosa Maria ;

Miano, Maurizio ;

Baselli, Lucia Augusta ;

Volpi, Stefano ;

Dufour, Carlo ;

Plebani, Alessandro ;

Aiuti, Alessandro ;

Lougaris, Vassilios ;

Fousteri, Georgia .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[4] MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer [J].

Dudda, Jan C. ;

Salaun, Bruno ;

Ji, Yun ;

Palmer, Douglas C. ;

Monnot, Gwennaelle C. ;

Merck, Estelle ;

Boudousquie, Caroline ;

Utzschneider, Daniel T. ;

Escobar, Thelma M. ;

Perret, Rachel ;

Muljo, Stefan A. ;

Hebeisen, Michael ;

Rufer, Nathalie ;

Zehn, Dietmar ;

Donda, Alena ;

Restifo, Nicholas P. ;

Held, Werner ;

Gattinoni, Luca ;

Romero, Pedro .

IMMUNITY, 2013, 38 (04) :742-753

[5] Ly6G+neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury [J].

Feng, Zunyong ;

Qi, Shimei ;

Zhang, Yue ;

Qi, Zhilin ;

Yan, Liang ;

Zhou, Jing ;

He, Fang ;

Li, Qianqian ;

Yang, Yanyan ;

Chen, Qun ;

Xiao, Shi ;

Li, Qiang ;

Chen, Yang ;

Zhang, Yao .

CELL DEATH & DISEASE, 2017, 8 :e3170-e3170

[6] Regulatory T cell lineage specification by the forkhead transcription factor FoxP3 [J].

Fontenot, JD ;

Rasmussen, JP ;

Williams, LM ;

Dooley, JL ;

Farr, AG ;

Rudensky, AY .

IMMUNITY, 2005, 22 (03) :329-341

[7] miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation [J].

Hu, Ruozhen ;

Kagele, Dominique A. ;

Huffaker, Thomas B. ;

Runtsch, Marah C. ;

Alexander, Margaret ;

Liu, Jin ;

Bake, Erin ;

Su, Wei ;

Williams, Matthew A. ;

Rao, Dinesh S. ;

Moeller, Thomas ;

Garden, Gwenn A. ;

Round, June L. ;

O'Connell, Ryan M. .

IMMUNITY, 2014, 41 (04) :605-619

[8] Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade [J].

Huffaker, Thomas B. ;

Lee, Soh-Hyun ;

Tang, William W. ;

Wallace, Jared A. ;

Alexander, Margaret ;

Runtsch, Marah C. ;

Larsen, Dane K. ;

Thompson, Jacob ;

Ramstead, Andrew G. ;

Voth, Warren P. ;

Hu, Ruozhen ;

Round, June L. ;

Williams, Matthew A. ;

O'Connell, Ryan M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (45) :18530-18541

[9] miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof [J].

Huffaker, Thomas B. ;

O'Connell, Ryan M. .

IMMUNITY, 2015, 43 (01) :3-4

[10] Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice [J].

Inagaki-Ohara, K ;

Sasaki, A ;

Matsuzaki, G ;

Ikeda, T ;

Hotokezaka, M ;

Chijiiwa, K ;

Kubo, M ;

Yoshida, H ;

Nawa, Y ;

Yoshimura, A .

GUT, 2006, 55 (02) :212-219

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