RETRACTED: Comprehensive Analysis of the Expression and Prognosis for E2Fs in Human Breast Cancer (Retracted article. See vol. 30, pg. 2639, 2022)

被引：125

作者：

Sun, Cheng-Cao ^{[1
,2
]}

Li, Shu-Jun ^{[3
]}

Hu, Wei ^{[1
]}

Zhang, Jian ^{[1
]}

Zhou, Qun ^{[1
]}

Liu, Cong ^{[1
]}

Li, Lin-Lin ^{[1
]}

Songyang, Yi-Yan ^{[1
]}

Zhang, Feng ^{[1
]}

Chen, Zhen-Long ^{[2
]}

Li, Guang ^{[4
]}

Bi, Zhuo-Yue ^{[5
]}

Bi, Yong-Yi ^{[1
]}

Gong, Feng-Yun ^{[6
]}

Bo, Tao ^{[6
]}

Yuan, Zhan-Peng ^{[1
]}

Hu, Wei-Dong ^{[7
]}

Zhan, Bo-Tao ^{[8
]}

Zhang, Qian ^{[9
]}

He, Qi-Qiang ^{[1
]}

Li, De-Jia ^{[1
]}

机构：

[1] Wuhan Univ, Sch Hlth Sci, Dept Occupat & Environm Hlth, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[3] Wuhan Hosp Prevent & Treatment Occupat Dis, Wuhan 430022, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Wuhan Pu Ai Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430034, Hubei, Peoples R China

[5] Hubei Prov Acad Prevent Med, Hubei Prov Key Lab Appl Toxicol, Wuhan 430079, Hubei, Peoples R China

[6] Wuhan Med Treatment Ctr, Dept Infect Dis, Wuhan 430071, Hubei, Peoples R China

[7] Wuhan Univ, ZhongNan Hosp, Dept Oncol, Wuhan 430071, Hubei, Peoples R China

[8] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Xiangyang 441021, Hubei, Peoples R China

[9] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pathol, Wuhan 430014, Hubei, Peoples R China

来源：

MOLECULAR THERAPY | 2019年 / 27卷 / 06期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

SUPPRESSES TUMOR-GROWTH; TRANSCRIPTION FACTOR; CELL-PROLIFERATION; GENE; MIGRATION; INVASION; OVEREXPRESSION; CONTRIBUTES; CARCINOMAS; RESISTANCE;

D O I：

10.1016/j.ymthe.2019.03.019

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

E2F transcription factors (E2Fs), a group of genes that encode a family of transcription factors, have been identified as being involved in the tumor progression of various cancer types. Increasing experimental evidence indicates that E2Fs are implicated in breast cancer tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be analyzed. Herein we investigated the transcriptional and survival data of E2Fs in patients with breast cancer from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier Plotter, and cBioPortal databases. We found that the expression levels of E2F1-3 and 5-8 were higher in breast cancer tissues than in normal breast tissues, whereas the expression level of E2F4 was lower in the former than in the latter. The expression levels of E2F2, 5, 7, and 8 were correlated with advanced tumor stage. Survival analysis using the Kaplan-Meier Plotter database revealed that the high transcription levels of E2F1-3, 5, 7, and 8 were associated with low relapse-free survival in all of the patients with breast cancer. Conversely, high E2F4 and E2F6 levels predicted high relapse-free survival in these patients. This study implied that E2F1-3, 5, 7, and 8 are potential targets of precision therapy for patients with breast cancer and that E2F4 and 6 are new bio-markers for the prognosis of breast cancer.

引用

页码：1153 / 1165

页数：13

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