3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

被引:18
作者
Bejaoui, Meriem [1 ]
Villareal, Myra O. [1 ,2 ,3 ]
Isoda, Hiroko [1 ,2 ,3 ]
机构
[1] Univ Tsukuba, Sch Integrat & Global Majors SIGMA, Tsukuba, Ibaraki, Japan
[2] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki, Japan
[3] Univ Tsukuba, Alliance Res Mediterranean & North Africa ARENA, Tsukuba, Ibaraki, Japan
基金
日本科学技术振兴机构;
关键词
3; 4; 5-tri-O-caffeoylquinic acid; β -catenin; melanocytes; anagen; melanogenesis enzymes; microphthalmia-associated transcription factor; melanin; TRANSCRIPTION FACTOR MITF; WNT/BETA-CATENIN; CADHERIN EXPRESSION; NEURAL CREST; STEM-CELLS; MELANOCYTE; SKIN; FATE; DIFFERENTIATION; MELANOGENESIS;
D O I
10.3389/fcell.2020.00175
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The hair follicle undergoes a regular cycle composed of three phases: anagen, catagen, and telogen. The life of follicular melanocytes is totally linked to the hair cycle; and during anagen or the growth phase, the melanocytes are active and produce the melanin responsible of hair shaft pigmentation. Various signaling pathways regulate the hair growth cycle and, therefore, the pigmentation; we distinguish the Wnt/beta-catenin signaling pathway as it plays a major role in the development, growth, and proliferation of the melanocytes and the activation of melanogenesis enzymes and the related transcription factor. In this study, 3,4,5-tri-O-caffeoylquinic acid (TCQA), a caffeoylquinic acid derivative, stimulated the pigmentation in C3H mouse hair follicle, in human melanocytes, and B16F10 melanoma cells. An enhancement in pigmentation associated genes was observed upon TCQA treatment in vivo and in vitro. Interestingly, the expression of beta-catenin was remarkably upregulated in mouse treated skin and in pigment cell lines. Moreover, TCQA upregulated CTNNB1 expression after inhibition in human melanocytes. Taken together, this study suggests that TCQA triggered beta-catenin activation to enhance the pigmentation during the anagen phase of the hair cycle.
引用
收藏
页数:14
相关论文
共 65 条
[51]   MELANOGENESIS IS COUPLED TO MURINE ANAGEN - TOWARD NEW CONCEPTS FOR THE ROLE OF MELANOCYTES AND THE REGULATION OF MELANOGENESIS IN HAIR-GROWTH [J].
SLOMINSKI, A ;
PAUS, R .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 101 (01) :S90-S97
[52]   Melanocyte stem cell maintenance and hair graying [J].
Steingrímsson, E ;
Copeland, NG ;
Jenkins, NA .
CELL, 2005, 121 (01) :9-12
[53]   Mitochondria's Role in Skin Ageing [J].
Stout, Roisin ;
Birch-Machin, Mark .
BIOLOGY-BASEL, 2019, 8 (02)
[54]   Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth [J].
Takabayashi, Yuki ;
Nambu, Masaki ;
Ishihara, Masayuki ;
Kuwabara, Masahiro ;
Fukuda, Koichi ;
Nakamura, Shingo ;
Hattori, Hidemi ;
Kiyosawa, Tomoharu .
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2016, 9 :127-134
[55]   The cell biology of human hair follicle pigmentation [J].
Tobin, Desmond J. .
PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (01) :75-88
[56]   Hair pigmentation: A research update [J].
Tobin, DJ ;
Hordinsky, M ;
Bernard, BA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2005, 10 (03) :275-279
[57]   The fate of hair follicle melanocytes during the hair growth cycle [J].
Tobin, DJ ;
Slominski, A ;
Botchkarev, V ;
Paus, R .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (03) :323-332
[58]   CD34 expression by hair follicle stem cells is required for skin tumor development in mice [J].
Trempus, Carol S. ;
Morris, Rebecca J. ;
Ehinger, Matthew ;
Elmore, Amy ;
Bortner, Carl D. ;
Ito, Mayumi ;
Cotsarelis, George ;
Nijhof, Joanne G. W. ;
Peckham, John ;
Flagler, Norris ;
Kissling, Grace ;
Humble, Margaret M. ;
King, Leon C. ;
Adams, Linda D. ;
Desai, Dhimant ;
Amin, Shantu ;
Tennant, Raymond W. .
CANCER RESEARCH, 2007, 67 (09) :4173-4181
[59]   Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation [J].
Tsai, Su-Yi ;
Sennett, Rachel ;
Rezza, Amelie ;
Clavel, Carlos ;
Grisanti, Laura ;
Zemla, Roland ;
Najam, Sara ;
Rendl, Michael .
DEVELOPMENTAL BIOLOGY, 2014, 385 (02) :179-188
[60]   Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes [J].
Villareal, Myra O. ;
Kume, Sayuri ;
Neffati, Mohamed ;
Isoda, Hiroko .
BIOMED RESEARCH INTERNATIONAL, 2017, 2017