Cell-penetrating Peptide-based Intelligent Liposomal Systems for Enhanced Drug Delivery

被引：96

作者：

Gao, Huile ^{[1
]}

Zhang, Qianyu ^{[1
]}

Yu, Zhiqiang ^{[2
]}

He, Qin ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

[2] Arizona State Univ, Biodesign Inst, Ctr BioEnerget, Tempe, AZ 85287 USA

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2014年 / 15卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cell penetrating peptides; liposomes; intelligent; TUMOR-CELLS; INTRACELLULAR DELIVERY; PEGYLATED LIPOSOMES; TARGETED DELIVERY; LIGAND LIPOSOMES; SOLID TUMOR; PH; NANOPARTICLES; INSERTION; DESIGN;

D O I：

10.2174/1389201015666140617092552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor selectivity of CPPs hindered their application, especially in the in vivo application. To resolve this issue, several strategies have been developed, including shielding and environment-triggered deshielding of CPPs as well as designing of environment-responsive CPPs and specific-targeting CPPs and last but not least, combination strategy. In this review, the abovementioned strategies were discussed.

引用

页码：210 / 219

页数：10

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