Bone remodeling in health and disease: Lessons from mathematical modeling

被引：13

作者：

Komarova, Svetlana V. ^{[1
]}

机构：

[1] McGill Univ, Fac Dent, Montreal, PQ H3A 2B2, Canada

来源：

SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING | 2006年 / 1068卷

关键词：

bone remodeling; power-law approximation; paracrine; autocrine; endocrine; basic multicellular unit;

D O I：

10.1196/annals.1346.052

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parathyroid hormone is the single anabolic treatment for osteoporosis currently approved by U.S. Food and Drug Administration. The physiology underlying anabolic actions of parathyroid hormone remains mysterious, since only when applied intermittently, does it increase bone mass. This study employs mathematical modeling to consider multiple concomitant effects of parathyroid hormone and local regulators on bone turnover. Remarkably, due to coupling between osteoclasts and osteoblasts, anabolic effects of parathyroid hormone emerged from a single action-stimulation of osteoclastic bone resorption. This study provides a novel conceptual framework for the development of highly desirable anabolic treatments for bone diseases.

引用

页码：557 / 559

页数：3