Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19

被引：29

作者：

Jeyaraman, Madhan ^{[1
,2
]}

John, Albin ^{[3
]}

Koshy, Santhosh ^{[3
]}

Ranjan, Rajni ^{[1
]}

Anudeep, Talagavadi Channaiah ^{[4
]}

Jain, Rashmi ^{[5
]}

Swati, Kumari ^{[8
]}

Jha, Niraj Kumar ^{[2
]}

Sharma, Ankur ^{[7
]}

Kesari, Kavindra Kumar ^{[6
]}

Prakash, Anand ^{[8
]}

Nand, Parma ^{[2
]}

Jha, Saurabh Kumar ^{[2
]}

Reddy, P. Hemachandra ^{[9
,10
,11
,12
,13
]}

机构：

[1] Sharda Univ, Sch Med Sci & Res, Dept Orthopaed, Greater Noida, Uttar Pradesh, India

[2] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India

[3] Texas Tech Univ, Internal Med, Hlth Sci Ctr, 3601 4th St MS 9410-4B 207, Lubbock, TX 79430 USA

[4] Topiwala Natl Med Coll & BYL Nair Ch Hosp, Dept Plast Surg, Mumbai, Maharashtra, India

[5] Sharda Univ, Sch Med Sci & Res, Greater Noida, Uttar Pradesh, India

[6] Aalto Univ, Sch Sci, Dept Appl Phys, Espoo, Finland

[7] Sharda Univ, Sch Basic Sci & Res, Dept Life Sci, Greater Noida, Uttar Pradesh, India

[8] Mahatma Gandhi Cent Univ, Sch Life Sci, Dept Biotechnol, Motihari, Bihar, India

[9] Texas Tech Univ, Hlth Sci Ctr, Internal Med Dept, 3601 4th St MS-9410-4B 207, Lubbock, TX 79430 USA

[10] Texas Tech Univ, Hlth Sci Ctr, Neurosci Pharmacol Dept, 3601 4th St MS-9410-4B 207, Lubbock, TX 79430 USA

[11] Texas Tech Univ, Hlth Sci Ctr, Neurol Dept, 3601 4th St MS-9410-4B 207, Lubbock, TX 79430 USA

[12] Texas Tech Univ, Hlth Sci Ctr, Publ Hlth Dept, 3601 4th St MS-9410-4B 207, Lubbock, TX 79430 USA

[13] Texas Tech Univ, Hlth Sci Ctr, Sch Hlth Profess, 3601 4th St MS-9410-4B 207, Lubbock, TX 79430 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2021年 / 1867卷 / 02期

关键词：

Coronavirus; COVID-19; WHO; Mesenchymal stem cells; HUMAN ADIPOSE-TISSUE; SUPPRESS T-LYMPHOCYTE; UMBILICAL-CORD; PROLIFERATION; DIFFERENTIATION; ACTIVATION; POLARIZATION; APOPTOSIS; MARKERS; MSCS;

D O I：

10.1016/j.bbadis.2020.166014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pandemic on the 11th of March 2020. Individuals with underlying systemic disorders have reported complications, such as cytokine storms, when infected with the virus. As the number of positive cases and the death toll across the globe continue to rise, various researchers have turned to cell based therapy using stem cells to combat COVID-19. The field of stem cells and regenerative medicine has provided a paradigm shift in treating a disease with minimally invasive techniques that provides maximal clinical and functional outcome for patients. With the available evidence of immunomodulatory and immune-privilege actions, mesenchymal stem cells (MSCs) can repair, regenerate and remodulate the native homeostasis of pulmonary parenchyma with improved pulmonary compliance. This article revolves around the usage of novel MSCs therapy for combating COVID-19.

引用

页数：10

共 82 条

[71] Ex Vivo Expanded Mesenchymal Stromal Cell Minimal Quality Requirements for Clinical Application [J].