Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes

被引：65

作者：

Bicknell, KA ^{[1
]}

Coxon, CH ^{[1
]}

Brooks, G ^{[1
]}

机构：

[1] Univ Reading, Sch Pharm, Cardiovasc Res Grp, Reading RG6 6AJ, Berks, England

来源：

BIOCHEMICAL JOURNAL | 2004年 / 382卷

关键词：

cardiomyocyte; CDC2; cell cycle; cell division; cyclin B;

D O I：

10.1042/BJ20031481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might reinitiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.

引用

页码：411 / 416

页数：6

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