Variations in cortisol sensitivity: The clinical implications of the polymorphisms in the glucocorticoid receptor gene

被引:0
作者
Lamberts, S. W. J. [1 ]
机构
[1] Erasmus MC, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands
关键词
ER22/23EK POLYMORPHISM; BODY-COMPOSITION; IN-VIVO; ASSOCIATION; EXPRESSION;
D O I
10.1016/j.bone.2009.07.040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S129 / S131
页数:3
相关论文
共 16 条
[1]   Generalized glucocorticoid resistance: Clinical aspects, molecular mechanisms, and implications of a rare genetic disorder [J].
Charmandari, Evangelia ;
Kino, Tomoshige ;
Ichijo, Takamasa ;
Chrousos, George P. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (05) :1563-1572
[2]   Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals [J].
Huizenga, NATM ;
Koper, JW ;
De Lange, P ;
Pols, HAP ;
Stolk, RP ;
Grobbee, DE ;
De Jong, FH ;
Lamberts, SWJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (01) :47-54
[3]   Two Polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression [J].
Russcher, H ;
Smit, P ;
van den Akker, ELT ;
van Rossum, EFC ;
Brinkmann, AO ;
de Jong, FH ;
Lamberts, SWJ ;
Koper, JW .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (10) :5804-5810
[4]   Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism [J].
Russcher, H ;
van Rossum, EFC ;
de Jong, FH ;
Brinkmann, AO ;
Lamberts, SWJ ;
Koper, JW .
MOLECULAR ENDOCRINOLOGY, 2005, 19 (07) :1687-1696
[5]   Molecular determinants of glucocorticoid receptor mobility in living cells: The importance of ligand affinity [J].
Schaaf, MJM ;
Cidlowski, JA .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (06) :1922-1934
[6]  
Stewart PM, 1999, VITAM HORM, V57, P249
[7]   Glucocorticoid receptor gene and risk of cardiovascular disease [J].
van den Akker, Erica L. T. ;
Koper, Jan W. ;
van Rossum, Elisabeth F. C. ;
Dekker, Marieke J. H. ;
Russcher, Henk ;
de Jong, Frank H. ;
Uitterlinden, Andre G. ;
Hofman, Albert ;
Pols, Huibert A. ;
Witteman, Jacqueline C. M. ;
Lamberts, Steven W. J. .
ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (01) :33-39
[8]   Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms [J].
van den Akker, Erica L. T. ;
Nouwen, Jan L. ;
Melles, Damian C. ;
van Rossum, Elisabeth F. C. ;
Koper, Jan W. ;
Uitterlinden, Andre G. ;
Hofman, Albert ;
Verbrugh, Henri A. ;
Pols, Huibert A. ;
Lamberts, Steven W. J. ;
van Belkum, Alex .
JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (06) :814-818
[9]   Glucocorticoid receptor polymorphism affects transrepression but not transactivation [J].
van den Akker, Erica L. T. ;
Russcher, Henk ;
van Rossum, Elisabeth F. C. ;
Brinkmann, Albert O. ;
de Jong, Frank H. ;
Hokken, Anita ;
Pols, Huibert A. P. ;
Koper, Jan W. ;
Lamberts, Steven W. J. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (07) :2800-2803
[10]   A polyntorphism in the glucocorticoid receptor gene, which decreases sensitivity to Glucocorticoids in vivo, is associated with low insulin and cholesterol levels [J].
van Rossum, EFC ;
Koper, JW ;
Huizenga, NATM ;
Uitterlinden, AG ;
Janssen, JAMJL ;
Brinkmann, AO ;
Grobbee, DE ;
de Jong, FH ;
van Duyn, CM ;
Pols, HAP ;
Lamberts, SWJ .
DIABETES, 2002, 51 (10) :3128-3134