Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia

被引：109

作者：

Mrozek, Krzysztof ^{[1
]}

Harper, David P. ^{[2
,3
]}

Aplan, Peter D. ^{[2
]}

机构：

[1] Ohio State Univ, Dept Internal Med, James Canc Hosp, Div Hematol & Oncol,Comprehens Canc Ctr, Columbus, OH 43210 USA

[2] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20889 USA

[3] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 05期

关键词：

Acute lymphoblastic leukemia; Gene mutations; Chromosome aberrations; Human; Prognosis; ACUTE MYELOID-LEUKEMIA; COMPARATIVE GENOMIC HYBRIDIZATION; IN-SITU HYBRIDIZATION; ONCOLOGY-GROUP POG; CHROMOSOMAL-ABNORMALITIES; PROGNOSTIC-SIGNIFICANCE; CLINICAL-SIGNIFICANCE; GROUP-B; INTRACHROMOSOMAL AMPLIFICATION; ADULT PATIENTS;

D O I：

10.1016/j.hoc.2009.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute lymphoblastic leukemia (ALL) is a malignant disease that often features nonrandom numerical or structural chromosome aberrations that can be detected microscopically. The application of contemporary genome-wide molecular analyses is revealing additional genetic alterations that are not detectable cytogenetically. This article describes the cytogenetic methodology and summarizes major cytogenetic findings and their clinical relevance in ALL. The article provides a review of modern molecular techniques and their application in the research on the genetics and epigenetics of ALL.

引用

页码：991 / +

页数：21

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