The role of prostatic inflammation biomarkers in the diagnosis of prostate diseases

被引：29

作者：

Bardan, Razvan ^{[1
]}

Dumache, Raluca ^{[2
]}

Dema, Alis ^{[3
]}

Cumpanas, Alin ^{[1
]}

Bucuras, Viorel ^{[1
]}

机构：

[1] Victor Babes Univ Med & Pharm, Dept Urol, Timisoara 300376, Romania

[2] Victor Babes Univ Med & Pharm, Dept Biochem, Timisoara 300376, Romania

[3] Victor Babes Univ Med & Pharm, Dept Pathol, Timisoara 300376, Romania

来源：

CLINICAL BIOCHEMISTRY | 2014年 / 47卷 / 10-11期

关键词：

Benign prostatic hyperplasia; Prostate cancer; Chronic inflammation; Biomarkers; EPITHELIAL GROWTH-FACTOR; URINARY-TRACT SYMPTOMS; PELVIC PAIN SYNDROME; C-REACTIVE PROTEIN; PHOSPHOLIPASE A(2); PARACRINE INDUCER; ELEVATED LEVELS; CELL-GROWTH; FACTOR-BETA; BENIGN;

D O I：

10.1016/j.clinbiochem.2014.02.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are chronic conditions, which are hormone-dependent and epidemiologically associated with prostate inflammation. As a large number of studies have demonstrated, the stimulation of T-cells at the level of prostatic chronic inflammatory infiltrates is followed by stromal and epithelial cell proliferation. The aim of this review is to present the actual level of knowledge in the field of prostatic immune response and chronic inflammation, and to analyze the relationships between chronic inflammation and BPH/PCa. The most studied prostatic inflammation biomarkers detected in biological fluids are also presented, together with their potential roles in the diagnosis and prognosis of prostatic disease. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：909 / 915

页数：7

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