Insight into the roles of vitamins C and D against cancer: Myth or truth?

被引：16

作者：

Zhao, Cai-Ning ^{[1
]}

Li, Ya ^{[1
]}

Meng, Xiao ^{[1
]}

Li, Sha ^{[2
]}

Liu, Qing ^{[1
]}

Tang, Guo-Yi ^{[1
]}

Gan, Ren-You ^{[3
]}

Li, Hua-Bin ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

[2] Univ Hong Kong, Sch Chinese Med, Li Ka Shing Fac Med, Hong Kong 999077, Hong Kong, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Food Sci & Engn, Sch Agr & Biol, Shanghai 200240, Peoples R China

[4] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2018年 / 431卷

基金：

中国国家自然科学基金;

关键词：

Vitamin C; Vitamin D; Calcitriol; Cancer; Mechanism; CELL LUNG-CANCER; BREAST-CANCER; D-RECEPTOR; D ANALOG; PROSTATE-CANCER; PHARMACOLOGICAL ASCORBATE; OVARIAN-CANCER; IN-VITRO; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; SYNTHETIC LETHAL;

D O I：

10.1016/j.canlet.2018.05.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The consumption of vitamins C and D for prevention and treatment of cancer is still an uncertain recommendation due to their controversial roles in cancer. The epidemiological studies document that vitamins C and D possess potential antineoplastic property. In addition, accumulating experimental studies strongly support their anticancer efficacy both in vitro and in vivo, although the mechanisms of action are not completely clear. Vitamin C at pharmacological concentration has cancer-selective cytotoxicity in several cancer cell lines. Moreover, the cognition of vitamin D has become "hormone D", which modulates a variety of molecular targets and signaling pathways, contributing to the inhibition of cancer. Furthermore, limited small-scale clinical trials favor their roles as the adjuncts of standard cancer therapies. On the other hand, opposite opinions also exist, and high-quality evidence are still lacking to ascertain the roles of vitamins C and Din cancer. In general, in light of the potential and promising anticancer values of vitamins C and D, it is essential to gain insight into their roles in cancer based on current epidemiological, experimental and clinical studies.

引用

页码：161 / 170

页数：10

共 128 条

[1] Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines [J].