Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

被引：4

作者：

Holstein, Sarah A. ^{[1
]}

Howard, Alan ^{[2
]}

Avigan, David ^{[3
]}

Bhutani, Manisha ^{[4
]}

Cohen, Adam D. ^{[5
]}

Costa, Luciano J. ^{[6
]}

Dhodapkar, Madhav, V ^{[7
]}

Gay, Francesca ^{[8
]}

Gormley, Nicole ^{[9
]}

Green, Damian J. ^{[10
,11
]}

Hillengass, Jens ^{[12
]}

Korde, Neha ^{[13
]}

Li, Zihai ^{[14
]}

Mailankody, Sham ^{[13
]}

Neri, Paola ^{[15
]}

Parekh, Samir ^{[16
]}

Pasquini, Marcelo C. ^{[17
]}

Puig, Noemi ^{[18
]}

Roodman, G. David ^{[19
]}

Samur, Mehmet Kemal ^{[20
]}

Shah, Nina ^{[21
]}

Shah, Urvi A. ^{[13
]}

Shi, Qian ^{[22
]}

Spencer, Andrew ^{[23
]}

Suman, Vera J. ^{[22
]}

Usmani, Saad Z. ^{[4
]}

McCarthy, Philip L. ^{[12
]}

机构：

[1] Univ Nebraska Med Ctr, Omaha, NE 68142 USA

[2] Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Levine Canc Inst, Charlotte, NC USA

[5] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[6] Univ Alabama Birmingham, Birmingham, AL USA

[7] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[8] Univ Torino, Azienda Osped Univ Citta Salute & Sci Torino, Div Hematol, Myeloma Unit, Turin, Italy

[9] US FDA, Silver Spring, MD USA

[10] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[11] Seattle Canc Care Alliance, Seattle, WA USA

[12] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

[13] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[14] Ohio State Univ, Columbus, OH 43210 USA

[15] Univ Calgary, Calgary, AB, Canada

[16] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[17] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[18] Univ Hosp Salamanca, Inst Biomed Res Salamanca, Salamanca, Spain

[19] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[20] Dana Farber Canc Inst, Boston, MA 02115 USA

[21] Univ Calif San Francisco, San Francisco, CA 94143 USA

[22] Mayo Clin, Rochester, MN USA

[23] Monash Univ, Alfred Hosp, Melbourne, Vic, Australia

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2020年 / 26卷 / 10期

关键词：

Minimal residual disease; Immune profiling; Multiple myeloma; Endpoint; CAR T cell; MULTIPLE-MYELOMA; BONE-MARROW; T-CELLS; GROWTH; MICROENVIRONMENT; RECOMMENDATIONS; PROGRESSION; INHIBITION; GAMMOPATHY; OUTCOMES;

D O I：

10.1016/j.bbmt.2020.06.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup has organized an annual workshop focused on minimal residual disease (MRD) testing and immune profiling (IP) in multiple myeloma since 2016. In 2019, the workshop took place as an American Society of Hematology (ASH) Friday Scientific Workshop titled "Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma." This workshop focused on 4 main topics: the molecular and immunologic evolution of plasma cell disorders, development of new laboratory- and imaging-based MRD assessment approaches, chimeric antigen receptor T cell therapy research, and statistical and regulatory issues associated with novel clinical endpoints. In this report, we provide a summary of the workshop and discuss future directions. (C) 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

引用

页码：E247 / E255

页数：9

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