Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research

被引：25
作者：
Drogemoller, Britt I. [1 ,2 ]
Wright, Galen E. B. [2 ,3 ]
Lo, Cody [2 ,4 ]
Le, Tan [1 ]
Brooks, Beth [5 ]
Bhavsar, Amit P. [6 ]
Rassekh, Shahrad R. [2 ,3 ]
Ross, Colin J. D. [1 ,2 ]
Carleton, Bruce C. [2 ,3 ]
机构：
[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
[2] BC Childrens Hosp, Res Inst, Vancouver, BC, Canada
[3] Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada
[4] Univ British Columbia, Fac Med, Vancouver, BC, Canada
[5] BC Childrens Hosp, Audiol & Speech Pathol Dept, Vancouver, BC, Canada
[6] Univ Alberta, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2019年 / 106卷 / 02期
基金：
加拿大健康研究院;
关键词：
SENSORINEURAL HEARING-LOSS; COMT GENETIC-VARIATION; DIABETES-MELLITUS; CHILDHOOD-CANCER; WOLFRAM-SYNDROME; RISK-FACTORS; WFS1; GENE; VARIANTS; TPMT; CHILDREN;
D O I：
10.1002/cpt.1483
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin-induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic variants associated with CIO; however, there has been a lack of consistency in the results that have been reported. This paper aims to provide an overview of the current state of CIO genomics research, delving into the shortcomings of past research, and providing recommendations for future avenues of study.
引用
收藏
页码：350 / 359
页数：10
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