Facile synthesis of thiazoles via an intramolecular thia-Michael strategy

被引：31

作者：

Sasmal, Pradip K. ^{[1
]}

Sridhar, S. ^{[1
]}

Iqbal, Javed ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Discovery Res, Hyderabad 500049, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 49期

关键词：

thiazoles; thia-Michael; benzotriazoles; desilylation;

D O I：

10.1016/j.tetlet.2006.09.157

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introduce various oxo and thio functionalities including aliphatic and aromatic moieties, especially at the C2-position of thiazoles. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8661 / 8665

页数：5

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