Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

被引：86

作者：

Montine, Thomas J. ^{[1
]}

Monsell, Sarah E. ^{[2
]}

Beach, Thomas G. ^{[3
]}

Bigio, Eileen H. ^{[4
,5
]}

Bu, Yunqi ^{[2
]}

Cairns, Nigel J. ^{[6
]}

Frosch, Matthew ^{[7
]}

Henriksen, Jonathan ^{[1
]}

Kofler, Julia ^{[8
]}

Kukull, Walter A. ^{[2
]}

Lee, Edward B. ^{[9
,10
,11
]}

Nelson, Peter T. ^{[12
,13
]}

Schantz, Aimee M. ^{[1
]}

Schneider, Julie A. ^{[14
,15
,16
]}

Sonnen, Joshua A. ^{[1
,22
]}

Trojanowski, John Q. ^{[9
,10
,11
]}

Vinters, Harry V. ^{[17
,18
,19
]}

Zhou, Xiao-Hua ^{[2
]}

Hyman, Bradley T. ^{[20
,21
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Natl Alzheimer Coordinating Ctr, Seattle, WA 98195 USA

[3] Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ USA

[4] Northwestern Univ Feinberg, Sch Med, Cognit Neurol & Alzheimers Dis Ctr, Chicago, IL USA

[5] Northwestern Univ Feinberg, Sch Med, Dept Pathol, Chicago, IL USA

[6] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[7] Massachusetts Gen Hosp, CS Kubik Lab Neuropathol, Dept Pathol, Charlestown, MA USA

[8] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA

[9] Univ Penn, Sch Med, Dept Pathol & Lab Med, Pittsburgh, PA USA

[10] Univ Penn, Sch Med, Ctr Neurodegenerat Dis Res, Pittsburgh, PA USA

[11] Univ Penn, Sch Med, Inst Aging, Pittsburgh, PA USA

[12] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[13] Univ Kentucky, Dept Pathol, Lexington, KY USA

[14] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[15] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[16] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[17] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med Neuropathol, Los Angeles, CA 90095 USA

[18] Ronald Reagan UCLA Med Ctr, Los Angeles, CA USA

[19] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[20] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA

[21] Massachusetts Gen Hosp, Massachusetts Alzheimers Dis Res Ctr, Charlestown, MA USA

[22] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Neuropathology; Methods; Whole-slide imaging; Multisite; BRAINNET EUROPE CONSORTIUM; ASSOCIATION GUIDELINES; NATIONAL INSTITUTE; AGREEMENT; PATHOLOGY;

D O I：

10.1016/j.jalz.2015.07.492

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods: Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results: Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted kappa = .88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion: AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：164 / 169

页数：6

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