Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system

被引：54
作者：
Jankowski, Vera [1 ]
van der Giet, Markus [1 ]
Mischak, Harald [2 ]
Morgan, Michael [3 ]
Zidek, Walter [1 ]
Jankowski, Joachim [1 ]
机构：
[1] Charite, Med Klin 4, D-12200 Berlin, Germany
[2] Mosaiques Diagnost & Therapeut AG, Hannover, Germany
[3] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, D-3000 Hannover, Germany
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2009年 / 157卷 / 07期
关键词：
dinucleoside polyphosphates; purinergic system; cardiovascular system; extracellular mediators; intracellular mediators; vascular tone; proliferation; VASCULAR SMOOTH-MUSCLE; VASOACTIVE DIADENOSINE POLYPHOSPHATES; URIDINE ADENOSINE-TETRAPHOSPHATE; P2 RECEPTOR SUBTYPES; ENDOTHELIAL-CELLS; EXTRACELLULAR ATP; PHARMACOLOGICAL CHARACTERIZATION; BIOCHEMICAL-EVIDENCE; INTERNATIONAL UNION; PLASMA-MEMBRANES;
D O I：
10.1111/j.1476-5381.2009.00337.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purinergic system is composed of mononucleosides, mononucleoside polyphosphates and dinucleoside polyphosphates as agonists, as well as the respective purinergic receptors. Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise. This review focuses on the overall impact of dinucleoside polyphosphates in the purinergic system. Platelets, adrenal glands, endothelial cells, cardiomyocytes and tubular cells release dinucleoside polyphosphates. Plasma concentrations of dinucleoside polyphosphates are sufficient to cause direct vasoregulatory effects and to induce proliferative effects on vascular smooth muscle cells and mesangial cells. In addition, increased plasma concentrations of a dinucleoside polyphosphate were recently demonstrated in juvenile hypertensive patients. In conclusion, the current literature accentuates the strong physiological and pathophysiological impact of dinucleoside polyphosphates on the cardiovascular system.
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收藏
页码：1142 / 1153
页数：12
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