Insights on Nuclease Mechanism: The Role of Proximal Ammonium Group on Phosphate Esters Cleavage

被引：35
作者：
Bonomi, Renato
Saielli, Giacomo
Tonellato, Umberto
Scrimin, Paolo
Mancin, Fabrizio [1 ]
机构：
[1] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 32期
关键词：
MONONUCLEAR ZN(II) COMPLEX; METAL-IONS; HYDROLYSIS; MODEL; COOPERATIVITY; REACTIVITY; CATALYSIS; ENZYMES; BINDING; DIESTER;
D O I：
10.1021/ja9033236
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The role of remotely located ammonium groups in the active site of many phosphate-cleaving enzymes is investigated by using model systems thus providing mechanistic hints to a stilt unsolved problem.
引用
收藏
页码：11278 / +
页数：4
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