Genetic association of CTLA4 gene with polycystic ovary syndrome in the Chinese Han population

被引:1
作者
Su, Jing [1 ]
Li, Yan [1 ]
Su, Guanglong [2 ]
Wang, Jing [1 ]
Qiu, Ting [1 ]
Ma, Rong [1 ]
Zhao, Lei [1 ]
机构
[1] Xinjiang Med Univ, Affiliated Hosp 1, Dept Gynecol, Urumqi Xinjiang, Peoples R China
[2] Maternal & Child Hlth Hosp Urumqi, Dept Clin Lab, Urumqi Xinjiang, Peoples R China
关键词
body mass index; cytotoxic T-lymphocyte-associated antigen 4; homeostatic model assessment for insulin resistance; polycystic ovary syndrome; single nucleotide polymorphism; INSULIN-RESISTANCE; PULMONARY TUBERCULOSIS; MEDICAL PROGRESS; OBESITY;
D O I
10.1097/MD.0000000000011422
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The autoimmune and gene etiology are implicated in the pathogenesis of polycystic ovary syndrome (PCOS). The cytotoxic Tlymphocyte-associated antigen 4 (CTLA4) is important for negative regulation of T-cell activation, and CTLA4 gene has been identified as a risk factor for some autoimmune diseases. However, none studies have been performed about the association between PCOS and the CTLA4 gene before. Here, we aimed to investigate the association of CTLA4 with PCOS in the Chinese Han population though a case-control association analysis of 606 individuals. The tagging variants rs733618 and rs231775 in the CTLA4 gene were detected using polymerase chain reaction-denaturing gradient gel electrophoresis method. Further analysis found the rs733618 was significantly different between case and control groups in either genotypic or allelic distribution (P=. 01 and.009, respectively) while rs231775 not. Moreover, rs733618 was significantly associated with higher body mass index in the dominant model (P=. 003) and with higher waist/hip ratio in the recessive model (P=. 02). Interestingly, rs733618 was only found to have significant association with homeostatic model assessment for insulin resistance (HOMA-IR) in both dominant and recessive model (P=. 009 and.0065, respectively). This is the first study to investigate the association of CTLA4 gene with PCOS. The CTLA4 gene is suggested to correlated with PCOS, and influence PCOS through regulating obesity and the HOMA-IR in a novel way.
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页数:5
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