Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

被引：213

作者：

Hershberg, RM ^{[1
]}

Mayer, LF

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[3] Mt Sinai Sch Med, Ctr Immunobiol, New York, NY 10029 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(99)01575-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg ann colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa.

引用

页码：123 / 128

页数：6

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